Seroprevalence of Hepatitis C Virus in the Urban Commune of Kindia-Republic of Guinea
Aissatou Boiro *
Guinean Applied Biology Research Institute (IRBAG) BP: 146 Kindia, Republic of Guinea.
Mamadou Gando Diallo
University of Kindia BP: 212 Kindia, Republic of Guinea.
Bonaventure Kolie
University of Kindia BP: 212 Kindia, Republic of Guinea.
Souleymane Diallo
University of Kindia BP: 212 Kindia, Republic of Guinea.
Abdoulaye Djibril Diallo
University of Kindia BP: 212 Kindia, Republic of Guinea.
Pévé Guilavogui
Regional Hospital of Kindia BP: 143 Republic of Guinea.
Mamadou Boundoukhoura Bah
Guinean Applied Biology Research Institute (IRBAG) BP: 146 Kindia, Republic of Guinea.
Thierno Amadou Labé Balde
Guinean Applied Biology Research Institute (IRBAG) BP: 146 Kindia, Republic of Guinea.
Sanaba Boumbaly
Centre for Virology Research/Guinea-Conakry Haemorrhagic Fever Laboratory, Republic of Guinea BP: 5680 Enta-Nord, Commune of Matoto, Conakry, Republic of Guinea.
Mamadou Yéro Boiro
Guinean Applied Biology Research Institute (IRBAG) BP: 146 Kindia, Republic of Guinea.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Hepatitis C is an inflammation of the liver caused by the hepatitis C virus; its spread in humans has been boosted by the emergence of parenteral use for medical purposes or drug injections, as well as its asymptomatic nature in the acute phase.
The global prevalence of hepatitis C is estimated at 1%, with a variable distribution in different regions of the world, sometimes even within the same country.
General objective: To help improve the biological diagnosis and prevention of HCV infections in the urban commune of Kindia.
Methodology: The urban commune of Kindia was used as the study area. This prospective and descriptive study was carried out at the Institut de Recherche en Biologie Appliquée de Guinée (IRBAG) from June to December 2022. The biomaterial consists of 3,000 blood samples taken from patients attending consultations at health facilities. The Immuno-Enzymatic technique (ELISA) was used to test for anti-HCV antibodies.
Results: In the course of our work, out of 3,000 samples taken from patients admitted to health facilities, 78 cases tested positive for the anti-HCV antibody, representing a carriage rate of 2.6%. Females were the most affected, with 50 positive cases (1.67%). The 31-40 age group had the highest anti-HCV antibody carriage rate, at 0.70%.
Conclusion: All socio-professional groups are affected by this infection, but to varying degrees. Despite our efforts, hepatitis C virus infection remains a major concern, as there is currently no vaccine and existing treatments are expensive and inaccessible to middle-income countries.
Keywords: Virus, Hepatitis C, anti-HCV Ab, elisa, Kindia
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References
World Health Organization WHO; Hepatitis C; 2023.
Irshad M, Raza MN, Anwar Z, Ikram N, Afroz A, Iqbal HM. Prevalence of viral HBV and HCV among different group patients in Gujrat Pakistan. Advances in Bioscience and Biotechnology. 2012 Aug 24;3(04): 423-36.
Gower E, Estes C, Blach S, Razavi-Shearer K, Razavi H. Global epidemiology and genotype distribution of the hepatitis C virus infection. J Hepatol. 2014;61:S45–S57. DOI:10.1016/j.jhep.2014.07.027
Nerrienet E, Pouillot R, Lachenal G, Njouom R, Mfoupouendoun J, Bilong C, et al. Hepatitis C virus infection in cameroon: A cohort-effect. J Med Virol. 2005;76:208–214. DOI:10.1002/jmv.20343.
Oumar Tangara : Hepatitis B hepatitis C co-infection in blood donors at the CNTS in Bamako ; Thèse pharm : 2004;57:61.
Lunel F, Cadranel JF, Perrin M, Grippon P, Desruenne M, et al. AntiHepatitis C virus antibodies in heart transplant recipients with post transplantation chronic viral B and non A non B hepatitis. Dig Dis Sci 1991;36:124-5.
Scheel TKH, Simmonds P, Kappoor A. surveying the global virome identification and characterisation of HCV related animal hepacivirus antiviral. 2015;115:83-93.
Balde TAL, Boumbaly S, EN. Serikova, Valutite DE, Shchemelev AN, Yu V Ostankova, Zueva EB, Semenov AV ; 2021.
Comparative Analysis of the Vertical Risk of Transmission of Some Blood-Borne Infections in the Republic of Guinea . DOI:https://doi.org/10.21055/0370-1069-2021-1-87-94
Daw MA, El-Bouzedi A, In association with Libyan Study Group of Hepatitis & HIV. Prevalence of hepatitis B and hepatitis C infection in Libya: results from a national population based survey. BMC Infect Dis. 2014;14:17 DOI:10.1186/1471-2334-14-17
Lavanchy D. Evolving epidemiology of hepatitis C virus. Clin Microbiol Infect. 2011;17:107–115. DOI:10.1111/j.1469-0691.2010. 03432. x
World Health Organization. Geneva: WHO; 2017. World hepatitis report 2017;83. Google Scholar.
Madhava V, Burgess C, Drucker E. Epidemiology of chronic hepatitis C virus infection in sub-Saharan Africa. Lancet Infect Dis. 2002;2:293–302.
Diakité F, Baldé MS, Bah A B, Traore M, Cherif I, Barry A Y, Bah A O, Kaba M L, Seroprevalence of viral hepatitis B and C and human immunodeficiency virus in chronic renal failure patients in the nephrology department of Donka National Hospital. 2019:28 à 33.
Boumbaly S, Serikova EN, Semenov AV, Ostankova YUV, Valutite DE, Schemelev AN, Zueva EB, Baldé TAL, Baimova RR, Totoliav AA, Importance of Biological Diagnosis of Parenteral Viral Hepatitis in the Republic of Guinea. Journal of Microbiology, Epidemiology and Immunology. Page 2021:440 à 449.
Medical Director of Livi France ; 2023.
Kalla, N., Aouidane, S., Megaache, F., & Tebbal, S. 2020. Prevalence of hepatitis C virus infection in the general population of Barika city. Batna J Med Sci. 2020;7:27-30.